硅酸盐学报

焦磷酸盐微晶玻璃对β-磷酸三钙生物陶瓷的抗弯强度及生物活性的影响

作者：于显著蔡舒许国华张喆李金恒王凤霞肖张莹曹丽凤

单位：天津大学先进陶瓷与加工技术教育部重点实验室上海长征医院天津大学先进陶瓷与加工技术教育部重点实验室天津大学先进陶瓷与加工技术教育部重点实验室天津大学先进陶瓷与加工技术教育部重点实验室天津大学先进陶瓷与加工技术教育部重点实验室天津大学先进陶瓷与加工技术教育部重点实验室天津大学先进陶瓷与加工技术教育部重点实验室天津300072 上海200003 天津300072 天津300072 天津300072 天津300072 天津300072 天津300072

关键词：焦磷酸盐玻璃 β-磷酸三钙力学性能生物活性

分类号：TQ174.1

出版年,卷(期):页码：2008,36(5):708-712

DOI：

摘要：

通过熔融法制备组成为Na2O-MgO-CaO-P2O5的基础玻璃,在800℃进行热处理,得到主要组成为Na4P2O7和β-Ca2P2O7(β-calcium pyrophosphate,β-DCP)的焦磷酸盐微晶玻璃(pyrophosphate glass,PG)。将PG和β-磷酸三钙(β-tricalcium phosphate,β-TCP)按质量比为10:90混合,干压成型,烧结制得PG/β-TCP生物陶瓷。采用差热分析、X射线衍射、扫描电镜、能谱、模拟体液浸泡等方法研究了基础玻璃的析晶、PG/β-TCP生物陶瓷材料体系的相组成、力学性能和生物活性。结果表明:PG能有效提高PG/β-TCP陶瓷的抗弯强度,1 300℃烧结3 h制备的PG/β-TCP陶瓷的弯曲强度与纯β-TCP陶瓷相比,由87.4 MPa提高至113.2 MPa;同时,PG可有效改善β-TCP基体的生物活性,在模拟体液中浸泡14 d后,PG/β-TCP陶瓷表面形成Ca与P摩尔比为1.46的叶状磷灰石。

Crystal pyrophosphate glass-ceramic(PG) consisting of Na4P2O7 and β-Ca2P2O7(β-DCP) was prepared by quenching CaO-P2O5 based glass with a composition of 62P2O5-14CaO-18Na2O-6MgO in air at room temperature,followed by heat treatment at 800 ℃.The PG/ beta-tricalcium phosphate(β-TCP) ceramic was fabricated by dry pressing and subsequent sintering of the mixture of PG and β-TCP powders with a mass ratio of 10:90.The crystal composition,mechanical property and bioactivity of the PG/β-TCP material and the crystallization of the CaO-P2O5 based glass were investigated by the differential thermal analysis,X-ray diffraction,scanning electron microscopy,energy dispersive X-ray analysis and simulated body solution dipping(SBF) methods.The results show that PG can significantly improve the bending strength of β-TCP material.The bending strength of PG/β-TCP material increases from 87.4 MPa to 113.2 MPa compared to pure β-TCP sintered at 1 300 ℃ for 3 h.In addition,the SBF dipping experiment shows that PG has positive effects on the improvement of the bioactivity of PG/β-TCP material.Leaf-like apatite particles with a Ca and P molar ratio of 1.46 were observed on the surface of the PG/β-TCP samples after the samples were soaked for 14 days in simulated body solution,but no similar structure was detected on the surface of pure β-TCP.

基金项目：

国家自然科学基金(50772072);; 天津市自然基金(06YFJMJC02900);; 上海市青年科技启明星计划(07QA14069)资助项目

作者简介：

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