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HAp/mSiO2载药颗粒的制备及体外药物释放行为
作者:李成峰1 高天宇1 贺立群1 陆昊1 葛筱璐2 
单位:1.山东理工大学材料科学与工程学院 山东淄博255049  2.山东理工大学理学院 山东淄博255049 
关键词:羟基磷灰石 介孔二氧化硅 核壳结构 药物载体 释放行为 
分类号:TB32
出版年,卷(期):页码:2014,42(4):464-470
DOI:10.7521/j.issn.0454-5648.2014.04.08
摘要:

以缓慢混合钙和磷前驱物溶液的化学沉淀法制备类球形羟基磷灰石(HAp)颗粒,通过正交实验法以高的吸附药物分子(亚甲基蓝)数量及低的标准偏差为依据确定溶胶­­凝胶工艺的最优条件,在疏硅醇性的HAp颗粒表面均匀沉积介孔二氧化硅(mSiO2)壳层,制备得到具有核壳结构的HAp/mSiO2颗粒,在0.10g/L的亚甲基蓝溶液中吸附量高达79.26mg/g,标准偏差为4.42。亚甲基蓝分子在颗粒上的吸附行为属于第II型吸附等温线,即分子以单体和二聚体的形式吸附在孔内。在磷缓冲液(pH7.27.4)Lysosome­like缓冲液(pH4.7)中药物分子自载药颗粒中的释放行为有明显的pH值敏感性能,这与溶液离子对载药颗粒结构和药物分子与载体间的作用机制的影响有关。

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Nano-sized spherical hydroxyapatite (HAp) particles were prepared via a wet chemical precipitation method after the solutions comprising calcium and phosphate precursors were mixed at a slow addition rate. According to the high adsorption capacity for drug (methylene blue, MB) and the standard deviation, the optimal experimental condition of sol-gel route was determined via the orthogonal experiment design method. The HAp/mesoporous silica (HAp/mSiO2) powder was fabricated through the deposition of mSiO2 on HAp at low silanophilic activity under the optimal experimental condition. The adsorption capacity of MB onto HAp/mSiO2 in solutions containing MB at a concentration of 0.10g/L is 79.26mg/g. The adsorption isotherm of methylene blue onto HAp/mSiO2 is a type II isotherm, i.e., the monomer and dimmers of drug molecules are adsorbed on HAp/mSiO2. The sustained-release behavior of drugs from HAp/mSiO2 is related to the pH value of the buffers (pH=7.2~7.4 in phosphate buffered saline and pH=4.7 in lysosome-like buffers) due to the influence of solution properties on the microstructures of drug carriers and interaction mechanisms between drug molecules and powders.
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基金项目:
山东理工大学博士基金(406017)项目资助;山东省高等学校科技计划项目(J11LD52);山东省自然科学基金(ZR2013EML008)项目资助。
作者简介:
第一作者:李成峰(1979—),博士,讲师。
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