Abstract: The flower-like NiO powder was firstly prepared by a homogeneous precipitation method, and then the powder was modified by yttria-stabilized zirconia(YSZ) to improve its high temperature resistance .The flower-like NiO powders modified by YSZ(i.e., NiO-YSZ powder)was fabricated via an ion impregnation method. The phase, microstructure and grain size and of the powder were characterized by thermogravimetry and differential thermal analysis, X-ray diffraction, scanning electron microscope, energy dispersive spectrometry and transmission electron microscopy, respectively. The two kinds of electrolyte-supported single cells were prepared with commercial and granular NiO powders and the flower-like NiO-YSZ powder as anodes, respectively. The composition of the single cells prepared with the flower-like NiO-YSZ powder is NiO+8YSZ‖8YSZ‖LSM+8YSZ. The electrochemical performance of the single cells was examined by electrochemical workstation. The results show that the maximum power density of the single cell prepared with the flower-like NiO-YSZ power as anode is 0.94, 0.151 and 0.376 W/cm2 at 750, 800 and 850 ℃, respectively, and the corresponding polarization resistance is 2.496, 1.589 and 0.814Ω•cm2, respectively. The maximum power density of the single cell prepared with commercial NiO power as anode is 0.024, 0.072  and 0.149 W/cm2  at 750, 800 and 850 ℃, respectively, and the corresponding polarization resistance is 4.265, 2.306 and 1.688 Ω•cm2, respectively.